Method for alteration detection
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United States of America Patent
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Issued Date -
Jun 10, 2004
app pub date -
Sep 9, 2003
filing date -
Mar 15, 2002
priority date (Note) -
Abandoned
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Abstract
Methods are provided for detecting an alteration or the absence of an alteration in a target nucleic acid. Methods of the invention are useful for detecting and identifying mutations that are indicative of disease or the predisposition for disease. Methods of the invention involve annealing a series of probes to a target nucleic acid and detecting the presence of a mutation in said target nucleic acid if one of the probes fails to anneal, thereby exposing a single stranded stretch of nucleic acid that is susceptible to degradation.
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