Method for detecting mutations in nucleotide sequences
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United States of America Patent
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Issued Date -
Jun 10, 2004
app pub date -
Nov 24, 2003
filing date -
Aug 4, 2000
priority date (Note) -
Abandoned
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Abstract
The invention relates to a method for simultaneously detecting mutations in different nucleotide sequences and for determining the transcription rate of mutated and non-mutated nucleotide sequences. The inventive method comprises the following steps: hybridizing single-stranded sample nucleotide sequences to single-stranded reference nucleotide sequences, fixating, before or during hybridization, single-stranded reference nucleotide sequences or single-stranded sample nucleotide sequences, or fixating, after or during hybridization, heteroduplices from reference and sample nucleotide sequences on an electronically addressable surface, incubating them with a substrate that recognizes heteroduplex mismatches, and detecting the substrate bonds.
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