Screening assay for antagonists of human leukocyte receptors
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United States of America Patent
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Issued Date -
Jun 3, 2004
app pub date -
Jun 20, 2003
filing date -
Dec 22, 2000
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Abandoned
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Abstract
A method of screening compounds for their ability of inhibiting ligand-induced co-stimulatory receptor internalisation pathways in immune competent human cells is described. The immune competent human cells are incubated at conditions capable of inducing co-stimulatory receptor internalisation in the presence of at least one test compound and the suppression of the ligand-induced co-stimulatory receptor internalisation is determined. There is also described a kit for use in such a method, as well as an immunoregulatory drug capable of blocking down-modulation of a ligand-induced receptor.
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