Acidified nitrite as an antimicrobial agent
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United States of America Patent
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app pub date -
Nov 3, 2003
filing date -
Feb 21, 1994
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Abandoned
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Abstract
The present invention provides a dosage form for the treatment of bacterial, viral or fungal conditions which comprises, a pharmaceutically acceptable acidifying agent in an amount sufficient to reduce the pH at an environment of use to below pH4, and a pharmaceutically acceptable source of nitrite ions or a nitrate precursor therefor; wherein said acidifying agent and said source of nitrite ions or nitrate precursor are separately disposed in respective pharmaceutically acceptable carriers for admixture at the intended environment of use to release NO or NO.sub.2 ions. The invention also provides delivery systems for the topical medicament.
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