Targets for therapeutic intervention identified in the mitochondrial proteome
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United States of America Patent
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Issued Date -
May 27, 2004
app pub date -
Apr 4, 2003
filing date -
Apr 12, 2002
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Abstract
Mitochondrial targets for drug screening assays and for therapeutic intervention in the treatment of diseases associated with altered mitochondrial function are provided. Complete amino acid sequences [SEQ ID NOS:1-3025] of polypeptides that comprise the human heart mitochondrial proteome are provided, using fractionated proteins derived from highly purified mitochondrial preparations, to identify previously unrecognized mitochondrial molecular components.
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