Method for producing microspherical crystallites from linear polysaccharides, corresponding microspherical crystallites and the suse thereof
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United States of America Patent
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Issued Date -
May 20, 2004
app pub date -
Jan 8, 2004
filing date -
Oct 26, 2000
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Abandoned
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Abstract
The invention relates to a method for producing microspherical crystallites with a uniform spherical shape and an extremely narrow size distribution. Said crystallites consist wholly or partially of a linear water-insoluble polysaccharide, preferably of 1,4-.alpha.-D-polyglucane, have a degree of crystallinity of >80% and can contain additional polymers and/or active ingredients, which are in particular biodegradable. They are particularly suitable for the controlled release of active ingredients. They are produced by fusing 1,4-.alpha.-D-polyglucane or the polysaccharide in water, introducing the fusion into a precipitant, cooling the mixture and separating the particles that have formed.
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