Process for synthesizing antifolates
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United States of America Patent
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Issued Date -
May 13, 2004
app pub date -
Jul 25, 2003
filing date -
Nov 13, 2002
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
This invention relates to a process for synthesizing certain folic acid analogues, which are useful in treating cancer, inflammatory diseases, autoimmune diseases, and are commonly referred to as antifolates. The process employs improved steps for annulation, derivatization and addition reactions to produce the described antifolates from commonly available starting materials.
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