Methods of drug delivery to hepatocytes and treatment of flaviviridae infections
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United States of America Patent
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app pub date -
Nov 28, 2003
filing date -
Aug 21, 2001
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Abandoned
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Abstract
A method of delivering a drug to a hepatocyte includes a step in which a carboxamidine group-containing compound is provided to a hepatocyte having a transporter that transports the compound across the plasma membrane of the hepatocyte, wherein the transport of the compound is substantially not inhibited by ribavirin. Further contemplated methods include a method of inhibiting growth of a virus of a family of flaviviridae in a cell containing system, in which contemplated compounds are presented to a cell in the cell containing system.
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