Pharmacologic, therapeutic and diagnostic regulation of FGF-1 export
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United States of America Patent
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app pub date -
Mar 6, 2003
filing date -
May 1, 1996
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Abstract
This invention relates to the regulation of FGF-1 export by cells. In addition, this invention provides methods of regulating the export of FGF-1 from the cell membrane, which methods include regulating the Syn-1 molecule to affect the formation of the FGF-Syn-1 complex, regulating the enzyme or protease which cleaves Syn-1 in the FGF-1 :Syn-1 complex to effect the release of FGF-1 from the cell membrane, or regulating the FGF-1:Syn-1 complex itself at or near the cell membrane. S100A13 is identified as an additional component of the FGF-1 export complex. Syn-1 truncation deletion mutants are also provided and functionally characterized. The invention also provides compositions related to the regulation of FGF-1 export.
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