In situ polymerizing medical compositions
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United States of America Patent
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Issued Date -
Apr 8, 2004
app pub date -
Aug 30, 2003
filing date -
Dec 12, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Isocyanate-capped biocompatible and optionally biodegradable polymers provide a liquid polymer composition, which can be implanted into a living mammal and which forms an adhesive, a coating, or a solid implant by in situ polymerization and crosslinking upon contact with body fluid or tissue. Formation of the polymerized material typically also involves crosslinking with surrounding tissue and formation of a tissue bond. Methods of using the novel liquid polymers of the invention in mammals are disclosed for providing wound sealing and bonding, formation of a protective barrier to prevent post-surgical adhesions, formation of tissue implants, and release of biologically active agents.
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