Importance

Loading Importance Indicators...

Abstract

The present invention relates to the method of treating cough with ORL-1 agonists, alone or in combination with additional agents for treating symptoms of cough, allergy or asthma, pharmaceutical compositions comprising the combinations, and to compounds of the formula 1 or a pharmaceutically acceptable salt or solvate thereof, wherein: the dotted line represents an optional double bond; X.sup.1 is optionally substituted alkyl, cycloalkyl, aryl, heteroaryl or heterocycloalkyl; X.sup.2 is --CHO, --CN, optionally substituted amino, alkyl, or aryl; or X.sup.1 is optionally substituted benzofused heterocyclyl and X.sup.2 is hydrogen; or X.sup.1 and X.sup.2 together form an optionally benzofused spiro heterocyclyl group R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently H and alkyl, or (R.sup.1 and R.sup.4) or (R.sup.2 and R.sup.3) or (R.sup.1 and R.sup.3) or (R.sup.2 and R.sup.4) together can form an alkylene bridge of 1 to 3 carbon atoms; Z.sup.1 is optionally substituted alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, or --CO.sub.2(alkyl or substituted amino) or CN ; Z.sup.2 is H or Z.sup.1; Z.sup.3 is H or alkyl; or Z.sup.1, Z.sup.2 and Z.sup.3, together with the carbon to which they are attached, form bicyclic saturated or unsaturated rings; pharmaceutical compositions therefore, and the use of said compounds as nociceptin receptor inhibitors useful in the treatment of pain, anxiety, cough, asthma, depression and alcohol abuse.

Loading the Abstract Image...

First Claim