Production of alpha-hydroxy-carboxylic acids using a coupled enzyme system
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United States of America Patent
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Issued Date -
Mar 18, 2004
app pub date -
Jun 9, 2003
filing date -
Oct 17, 2000
priority date (Note) -
Abandoned
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Abstract
An economical and expedient method is disclosed for the preparation of .alpha.-hydroxy-carboxylic acids or salts thereof in very high enantiomeric purity which comprises oxidizing a corresponding .alpha.-amino-carboxylic acid or salt thereof using an amino acid deaminase followed by reducing the corresponding .alpha.-keto-carboxylic acid or salt produced using a D- or L-lactate dehydrogenase in the combination with an electron donor and an enzyme/substrate system for recycling the electron donor. The resulting .alpha.-hydroxy-carboxylic acids, hydrates, and salts thereof are valuable components and intermediates in the preparation of chiral compounds, especially pharmaceuticals. This invention also relates to the use of .alpha.-amino-carboxylic acids, hydrates, and salts thereof and a coupled enzyme system in the production of .alpha.-hydroxy-carboxylic acids, hydrates, and salts thereof.
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