Expression and export of anti-obesity proteins as Fc fusion proteins
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United States of America Patent
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Issued Date -
Mar 18, 2004
app pub date -
Apr 18, 2003
filing date -
Jan 7, 1999
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Abandoned
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Abstract
Disclosed are nucleotide sequences, for example, DNA or RNA sequences, which encode an immunoglobulin Fc-Leptin fusion protein. The nucleotide sequences can be inserted into a suitable expression vector and expressed in mammalian cells. Also disclosed is a family of immunoglobulin Fc-Leptin fusion proteins that can be produced by expression of such nucleotide sequences. Also disclosed are methods using such nucleotide sequences and fusion proteins for treating conditions which are alleviated by the administration of leptin.
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