Detection and evaluation of topoisomerase inhibitors using optophoretic analysis

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United States of America Patent

SERIAL NO

10326885

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A method for identifying the inhibitory potential of a chemical compound to inhibit DNA topoisomerase I includes the steps of providing a population of cells, treating the population of cells to different concentrations of the chemical compound, and subjecting the treated cells to whole-cell optical interrogation to determine whether the chemical compound affected any cells within the population of cells. The method can also be applied to identify cells that are resistant to DNA topoisomerase I inhibitors.

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GENOPTIX INC3398 CARMEL MOUNTAIN ROAD SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chung, Thomas DY Carlsbad, CA 9 235
Kariv, Ilona A Carlsbad, CA 3 28
Lykstad, Kristie L San Diego, CA 14 755

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