Hepatotropic conjugates of antiblastic drugs accomplishing a loco-regional chemotherapy of liver micrometastases after adminstration by peripheral venous route

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United States of America Patent

APP PUB NO 20040044178A1
SERIAL NO

10250875

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Pharmaceutical compositions containing as active compound conjugates of lactosaminated albumin with antiblastic nucleosides (and their analogs) are here described. These compositions are particularly useful to increase the efficacy of the antiblastic nucleosides (and their analogs) on liver micrometastases. They preferably consist of aqueous solutions administered by parenteral route, preferably by intravenous injection. The antiblastic nucleoside of choice is 5-fluoro-2'-deoxyuridine (FUdR).

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UNIVERSITA' DI BOLOGNA40126 BOLOGNA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Busi, Corrado Bologna, IT 6 12
Di, Stefano Giuseppina Bologna, IT 4 2
Fiume, Luigi Bologna, IT 8 40

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