Penicillin production using transgenic merodiploid strains
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United States of America Patent
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Issued Date -
Mar 4, 2004
app pub date -
Sep 4, 2002
filing date -
Dec 10, 1999
priority date (Note) -
Abandoned
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Abstract
The object of this invention is a procedure for obtaining a genetically altered merodiploid strain of Penicillium chrysogenum in which the activity of a regulating gene that controls penicillin biosynthesis has been altered, so that this strain is an overproducer of penicillin. This invention represents the first case in which the biosynthesis of a metabolite of industrial interest has been increased by the manipulation of a regulating gene, and therefore is a considerable novelty compared with the previously used technologies.
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