Javelinization of protein antigens to heat shock proteins
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United States of America Patent
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Issued Date -
Mar 4, 2004
app pub date -
Aug 13, 2003
filing date -
Apr 17, 2001
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Abandoned
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Abstract
The present invention relates to antigenic complexes, wherein an antigenic complex comprises a peptide or protein containing a plurality of epitopes non-covalently joined to a heat shock protein via a molecular tether referred to as a 'javelin'. Such complexes do not require that each epitope Be defined, and may in certain embodiments, elicit both antibody and cell-mediated immune reactions. The complexes of the invention may be used to induce therapeutic immune responses directed toward the treatment or prevention of infectious diseases and malignancies.
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