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Abstract

2,2-Diphenylbutanamide derivatives represented by the following formula (1): 1 [wherein A represents --(CH.sub.2).sub.n-- (n is 1 or 2) or a methine (CH) group; when A is --CH.sub.2--, B represents a methine group or a nitrogen atom, with A and B forming a single bond; when A is --(CH.sub.2).sub.2--, B represents a nitrogen atom, with A and B forming a single bond; when A is a methine group, B represents a quaternary carbon atom, with A and B forming a double bond; each of R.sup.1 and R.sup.2, which are identical to or different from each other, represents a hydrogen atom, a lower alkyl group, or a cycloalkyl group, or R.sup.1 and R.sup.2 may form a heterocyclic ring together with the adjacent nitrogen atom; and Ar represents an optionally substituted phenyl group, bicyclic aromatic ring, monocyclic heterocyclic ring, bicyclic heterocyclic ring, or fluorene group]; or salts of the derivatives. The derivatives or salts thereof exhibit excellent .mu.-opioid agonist activity and analgesic activity against neuropathic pain, and are useful as medicines such as peripheral analgesic drugs and neuropathic pain relieving drugs.

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First Claim