Whole cell engineering using real-time metabolic flux analysis
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United States of America Patent
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Issued Date -
Feb 19, 2004
app pub date -
Oct 1, 2002
filing date -
Oct 1, 2001
priority date (Note) -
Abandoned
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Abstract
The invention provides methods for whole cell engineering of new and modified phenotypes by using 'on-line' or 'real-time' metabolic flux analysis. The invention provides a method for whole cell engineering of new or modified phenotypes by using real-time metabolic flux analysis by making a modified cell by modifying the genetic composition of a cell and culturing the modified cell to generate a plurality of modified cells and measuring at least one metabolic parameter of the cell by monitoring the cell culture of in real time. The invention also provides articles comprising machine-readable medium including machine-executable instructions and systems, e.g., computer systems, to practice the methods of the invention.
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