Integration of high cell density bioreactor operation with ultra fast on-line downstream processing
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United States of America Patent
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Issued Date -
Feb 19, 2004
app pub date -
Jan 15, 2003
filing date -
Jul 25, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention is related to a recovery and purification method of (a) biological(s) of interest produced by cells retained in a bioreactor under appropriate conditions and by appropriate means for producing the biological(s) inside the bioreactor having a volume higher than 1,5 l culture, and cultivated at a high cell density, preferably at a cell density higher than 10.times.10.sup.6 cells/ml, said bioreactor being submitted to an acoustic sonoperfusion allowing the recovery of a sonoperfused medium from said bioreactor, characterised in that it is submitted thereafter directly to an Expanded Bed Specific Adsorption for the direct recovery and uninterrupted purification of said biological(s). The present invention is also related to a process unit for recovering and purifying said biological(s) of interest.
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