Injection system for gene delivery
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United States of America Patent
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Issued Date -
Feb 12, 2004
app pub date -
Jun 11, 2003
filing date -
Jun 22, 2000
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Abandoned
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Abstract
An injection catheter is provided with a piezoelectric ultrasound emitting device atits distal end, capable of emitting ultrasound of different energy levels. It can be used to image the location of penetration of an internal organ of a patient by the catheter needle, by supply of echocontrast material through the needle and analysis of the ultrasound reflections therefrom. It can also be used to cause tissue perturbation or disruption at the imaged location, e.g. to initiate tissue angiogenesis, by choice of suitable ultrasound energy level of emission, and for delivery of therapeutic substances such as DNA to the disrupted tissue, for better uptake in gene therapy.
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