Method of screening for substances acting on MSK1
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United States of America Patent
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Issued Date -
Jan 22, 2004
app pub date -
Jun 3, 2003
filing date -
Oct 13, 1999
priority date (Note) -
Abandoned
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Abstract
In a method of identifying substances acting as inhibitors of NF-.kappa.B activation by MSK1 or MSK2, MSK1 or MSK2 are contacted with a predetermined amount of one or more test substances in the presence of an NF-.kappa.B subunit or a complex of NF-.kappa.B subunits, and a test substance is identified as an inhibitor of NF-.kappa.B activation by determining a decrease in NF-.kappa.B activation by MSK1 or MSK2 in the presence of said test substance compared to the level of NF-.kappa.B activation in the absence of said test substance.
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