Kinase crystal structures and materials and methods for kinase activation
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United States of America Patent
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Issued Date -
Jan 15, 2004
app pub date -
Aug 14, 2002
filing date -
Aug 14, 2001
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Abstract
Disclosed are crystallisable mutants of protein kinase B/Akt, crystals of these mutants, and X-ray coordinate data for the crystals. Methods of use of the coordinate data for identification of modulators of protein kinase activity and for structural analysis of other protein kinases are provided. Also provided are methods of activating protein kinases, in particular AGC kinases, using peptide or non-peptide mimetics of sequences from protein kinase B/Akt, or other AGC protein kinases such as PRK2.
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