Identification of compounds which stimulate bone formation using a cell-based screening assay targeting BMP signaling
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United States of America Patent
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Issued Date -
Jan 15, 2004
app pub date -
Apr 24, 2003
filing date -
Apr 24, 2002
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Abandoned
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Abstract
Methods and compositions for measuring the effects of molecules which stimulate BMP and Cbfa1 signaling are disclosed, wherein the response elements in the Smad family and Cbfa1 are utilized in an assay system to modulate the production of an assayable product of a reporter construct.
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