Multidose antibody formulation

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United States of America Patent

APP PUB NO 20040009168A1
SERIAL NO

10409477

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention is directed to a multidose pharmaceutical formulation comprising an antibody with one or more preservatives. This formulation is effective in inhibiting the growth of microorganisms. This formulation further retains the physical, chemical, and biological stability of the antibody molecule. In one embodiment of the invention, the pharmaceutical formulation comprises an IgG antibody, 0.15-0.2% (w/v) chlorobutanol, and 0.3-0.5% (w/v) benzyl alcohol. In another embodiment of the invention, the pharmaceutical formulation comprises an IgG antibody, 0.1-0.2% (w/v) chlorobutanol, and 0.05-0.1% (w/v) methyl paraben. In yet another embodiment of the invention, the pharmaceutical formulation comprises an IgG antibody and 0.5-0.75% benzyl alcohol.

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Patent Owner(s)

Patent OwnerAddress
PROTEIN DESIGN LABS INC3181 PORTER DRIVE PALO ALTO CA 94304

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gupta, Supriya Sunnyvale, CA 39 506
Kaisheva, Elizabet Belmont, CA 3 22

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