Kinase crystal structures
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Issued Date -
Jan 8, 2004
app pub date -
Aug 14, 2002
filing date -
Aug 14, 2001
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Abandoned
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Abstract
Disclosed are mutants of protein kinase B/Akt which can be crystallised in an enzymatically active conformation, crystals of these mutants and X-ray coordinate data for the crystals. Also disclosed are methods of using the coordinate data provided for identification of modulators of protein kinase activity and for structural analysis of other protein kinases, in particular AGC kinases.
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