Atherosclerosis vaccine
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Issued Date -
Jan 1, 2004
app pub date -
Dec 19, 2002
filing date -
Mar 15, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention relates to an antigenic composition capable of eliciting antibodies by interacting with .alpha..beta. chains of a T cell receptor (TcR), which composition is comprised of a peptide-aldehyde conjugate. The aldehyde portion may be a dialdehyde, such as malondialdehyde (MDA), or a monoaldehyde, such as 4-hydroxynonenal (4-HNE), while the peptide portion preferably comprises at least one lysine residue. The antigenic composition according to the invention is capable of recognizing and interacting with a TcR having a complementarity-determining region 3 (CDR3) of .alpha.10 and .beta.6 chains that comprises a cluster of charged and polar amino acids. The invention also relates to a method of producing a vaccine against atherosclerosis by screening of a library of candidate compounds for their ability to bind to a conjugate of oxidized LDL and a dialdehyde as well as to such a vaccine as such.
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