Viral removal
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United States of America Patent
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app pub date -
Mar 13, 2003
filing date -
Dec 23, 1998
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Abandoned
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Abstract
Methods for removing a non-enveloped virus from a sample containing a target compound and non-enveloped virus contamination place the sample containing the target compound in a solvent chamber of an electrophoresis apparatus having a cathode and an anode, and a first solvent chamber being separated from a second solvent chamber by a separation barrier that has a defined pore size. The solvent chambers and the separation barrier are located between the cathode and anode. A solvent is selected having a defined pH for the first solvent chamber, and a solvent is also added to the second solvent chamber. Applying an electric potential between the cathode and anode separates at least a portion of target compound on one side of the barrier and virus on the other side of the barrier. This applying step is maintained until a desired purity of the target compound is achieved.
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