Synthesis of synthons for the manufacture of bioactive compounds
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United States of America Patent
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Issued Date -
Dec 18, 2003
app pub date -
Mar 14, 2003
filing date -
Mar 14, 2002
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Abandoned
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Abstract
The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4) and variants therefor can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor aldehydes. The reaction products typically contain at least two new stereogenic centers and can be produced in enantiomerically pure form. As such, DERA catalyzed asymmetric aldol chemistry can be exploited to produce synthons for the synthesis of a variety of bioactive molecules.
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