Barbituric acid analogs as therapeutic agents
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United States of America Patent
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Issued Date -
Dec 11, 2003
app pub date -
May 21, 2003
filing date -
Jun 5, 2000
priority date (Note) -
Abandoned
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Abstract
This invention pertains to active barbituric acid analogs which inhibit HIF-1 activity (e.g., the interaction between HIF-1.alpha. and p300) and thereby inhibit angiogenesis, tumorigensis, and proliferative conditions, such as cancer. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HIF-1 activity, and to inhibit angiogensis, tumorigensis, and proliferative conditions, such as cancer.
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