Compositions and methods for viral delivery
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United States of America Patent
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Issued Date -
Dec 11, 2003
app pub date -
Oct 29, 2002
filing date -
Oct 31, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Compositions and methods comprising a recombinant virus and an immunostimulant are provided for enhancing the immune response to a polypeptide expressed from the recombinant virus. Preferably this is done without also enhancing the neutralizing antibody response to the recombinant virus. Illustrative compositions comprise an adenovirus and an adjuvant such as, for example, monophosphoryl lipid A, an alkyl glucosaminide phosphate, a saponin, or a combination thereof. The disclosed compositions and methods are useful, for example, in the treatment of diseases such as cancer or infectious disease.
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