Dosing regimen for gemcitabine HCV therapy
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United States of America Patent
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Issued Date -
Dec 4, 2003
app pub date -
Feb 14, 2003
filing date -
Feb 14, 2002
priority date (Note) -
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Abstract
A dosage regiment for the treatment of a Flaviviridae infection, including a hepatitis C viral infection, that includes administering gemcitabine (or its salt, prodrug or derivative, as described herein) in a dosage range of approximately 50 mg/m.sup.2 to about 1300 mg/m.sup.2 per day for between one and seven days (e.g. 1, 2, 3, 4, 5, 6, or 7 days) followed by cessation of therapy. Viral load is optionally monitored over time, and after cessation, viral rebound is monitored. Therapy is not resumed unless a significant viral load is again observed, and then therapy for 1-7 days and more preferred, 1, 2 or 3 days, is repeated. This therapy can be continued indefinitely to monitor and maintain the health of the patient.
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