Adenoviral p53 gene transfer in the prevention and treatment of injury-induced vascular smooth muscle cell proliferation
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United States of America Patent
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Issued Date -
Dec 4, 2003
app pub date -
May 9, 2003
filing date -
May 9, 2002
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Abstract
The present invention provides for the use of expression constructs encoding the tumor suppressor p53 for the prevention or treatment of vascular stenosis caused by vascular smooth muscle cell (VSMC) proliferation and/or migration in response to vascular trauma. This p53 therapy may be used in conjunction with other therapies including secondary gene therapy, anti-thrombotics or anti-inflammatory agents.
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