Conjugate of biodegradable aliphatic polyester with Tat49-57 peptide or peptide chain containing Tat49-57 peptide and nanoparticle manufactured using the same
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United States of America Patent
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Issued Date -
Nov 27, 2003
app pub date -
Jun 28, 2002
filing date -
May 17, 2002
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Abandoned
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Abstract
Conjugates of a biodegradable aliphatic polyester-based polymer with Tat.sub.49-57 peptide or a peptide chain containing the Tat.sub.49-57 peptide, and nanoparticles manufactured using the same. Intracellular permeability of the Tat.sub.49-57 peptide can be enhanced by exposing Tat peptide moieties to the surface of the nanoparticles.
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