Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1
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United States of America Patent
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Issued Date -
Nov 27, 2003
app pub date -
Apr 22, 2003
filing date -
Apr 3, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention relates to the use of aminothiazole derivatives of Formula I of as inhibitors of PAI-1, and to novel classes of aminothiazole derivatives, their synthesis and their use as inhibitors of PAI-1. It has been discovered that compounds of Formula I: 1 or a solvate, hydrate or a pharmaceutically acceptable salt thereof, wherein Y, Ar.sup.1, Ar.sup.2, R.sup.1, R.sup.2, Z, m and n are described in the specification, inhibit plasminogen activator inhibitor-1 (PAI-1). These compounds can be used in the prophylaxis or for the treatment of thrombosis, angina pectoris, cerebral infarction, myocardial infarction, pulmonary infarction, intra-atrial thrombus in atrial fibrillation, deep venous thrombus, disseminated intravascular coagulation syndrome, diabetic complications, restenosis and stroke.
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