Extensive myocardial infarction model animal, method for preparation there of, and application for drug screening and regenerative medicine
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United States of America Patent
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Issued Date -
Nov 13, 2003
app pub date -
May 9, 2002
filing date -
May 9, 2002
priority date (Note) -
Abandoned
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Abstract
The prior art has problems such as high mortality of model animals due to complication of heart failure, necessity of taking into consideration the effects from other organs for investigation of the mechanism of the disease, being unable to prepare an extensive myocardial infarction model, and others. The invention allows exclusion of the state of heart failure and provides an extensive myocardial infarction model animal which permits to prepare a model of the pathology of extensive myocardial infarction. The invention is an extensive myocardial infarction model animal, the method for preparation thereof, and the method for screening of drugs and/or genes using the model animal, wherein the heart of a normal animal is extirpated, the left main trunk of the extirpated heart is ligated, the heart after the ligation is heterotopically grafted to the abdomen of another normal animal, and the animal given the heterotopic graft is used as the extensive myocardial infarction model animal. Three weeks after the graft, the model of extensive myocardial infarction pathology is established.
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