Optophoretic detection of durgs exhibiting inhibitory effect on Bcr-Abl positive tumor cells

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United States of America Patent

APP PUB NO 20030211461A1
SERIAL NO

10326598

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Abstract

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A method of screening for inhibitors of the Bcr-Abl tyrosine kinase enzyme using a moving optical gradient includes the steps of providing a panel of cell lines having, on average, different copy numbers of the gene that produces the Bcr-Abl tyrosine kinase enzyme, exposing the panel of cell lines with a chemical compound, moving the cells in the panel of cell lines and the optical gradient relative to each other so as to cause displacement of at least some of the cells, measuring the displacement of at least a portion of the displaced cells in each cell line, and comparing the measured displacements with measured displacements from control cells from each cell line that have not been treated with the chemical. The comparison step determines whether the chemical compound is an inhibitor of the Bcr-Abl tyrosine kinase enzyme.

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GENOPTIX INC3398 CARMEL MOUNTAIN ROAD SAN DIEGO CA 92121

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Inventor Name Address # of filed Patents Total Citations
Chung, Thomas DY Carlsbad, CA 9 235
Forster, Anita Santee, CA 7 107
Hall, Jeffrey M Carlsbad, CA 7 197
Kariv, Ilona A Carlsbad, CA 3 28

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