Method of screening therapeutic agents
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Issued Date -
Nov 6, 2003
app pub date -
Aug 28, 2000
filing date -
Feb 6, 1998
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Abandoned
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Abstract
The invention relates to a method for screening therapeutic agents for use in combating diseases associated with gene regulation by one or more Smad proteins and TGF&bgr; or activin, said method comprising detecting or assaying the extent or result of transcriptional activity or binding in the presence of said agent between a Smad protein or a DNA binding fragment thereof and a double strand oligonucleotide comprising the sequence 5' WXYCAGACZ 3' or a functional equivalent thereof, wherein in said nucleotide sequence W represents A or G, X represents G or T, Y represents C, A, G or T and Z represents A or C. Also claimed are therapeutic agents identified by such a method and their use in combating diseases associated with abnormal expression of Smad-mediated TGF&bgr;-induced genes.
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