Compounds and methods for the treatment of neoplastic disease
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United States of America Patent
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Issued Date -
Oct 30, 2003
app pub date -
May 20, 2003
filing date -
Jul 25, 2001
priority date (Note) -
Abandoned
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Abstract
A method of modulating the activity of a aberrant cell topoisomerase enzyme involving contacting the enzyme with a compound that inhibits enzyme-mediated cleavage of a polynucleotide substrate with which the enzyme is in complex. Pharmaceutical compositions containing such compounds may be used to treat neoplasias or to inhibit the growth of certain cancer cells. Screening methods can be employed to identify other compounds for these uses.
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