Multiplex detection of biological materials in a sample
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United States of America Patent
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Issued Date -
Oct 30, 2003
app pub date -
Mar 6, 2003
filing date -
Mar 8, 2002
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Abandoned
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Abstract
The present invention relates to a method of detecting target nucleic acid molecules in a sample. This method involves providing a plurality of different groups of two or more electrically separated electrical conductors with capture probes attached to the conductors such that a gap exists between the capture probes on the electrically separated conductors. The capture probes are contacted with a sample, potentially containing the target nucleic acid molecules, under conditions effective to permit any of the target nucleic acid molecule present in the sample to hybridize to the capture probes and thereby connect the capture probes. The presence of the target nucleic acid molecules is detected by determining whether electricity is conducted between the electrically separated conductors. Devices for carrying out this method are also disclosed.
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