Signal amplifying targeted reporters for biological and chemical sensor applications
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United States of America Patent
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Issued Date -
Oct 23, 2003
app pub date -
Apr 1, 2002
filing date -
Apr 1, 2002
priority date (Note) -
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Abstract
The present invention provides targeted dendrimeric reporter molecules that provide amplified signals at electrochemical sensors, and methods of synthesis and methods of use thereof. The reporter molecules comprise a targeting moiety and at least one dendritic signal amplifier; the dendritic amplifier comprises a plurality of dendritic branches and a plurality of indicator moieties, typically pendant therefrom. The targeting moiety serves to concentrate the dendritic amplifier at a selected target, where the plural indicator provide increased signals.
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