Early detection of apoptotic events and apoptosis using optophoretic analysis
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United States of America Patent
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Issued Date -
Oct 16, 2003
app pub date -
Dec 19, 2002
filing date -
Apr 27, 2001
priority date (Note) -
Abandoned
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Abstract
A method for detecting the onset of apoptosis in cells using a moving optical gradient includes the steps of exposing at least a portion of the cells to at least one chemical compound, moving the cells and the optical gradient relative to each other so as to cause displacement of at least some of the cells, measuring the displacement of at least a portion of the displaced cells, comparing the measured displacement with the measured displacement of at least one control cell that has not been treated with the at least one chemical compound. The step of comparing the measured displacement of the control and tested cells determines the onset of apoptosis. Methods are also provided for monitoring cells throughout apoptosis.
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