Pharmaceutical compositions and methods of use thereof comprising polyanionic polymers and amphiphilic block copolymers to improve gene expression
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United States of America Patent
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Issued Date -
Oct 9, 2003
app pub date -
Dec 26, 2002
filing date -
Dec 28, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention is directed to polynucleotide compositions containing (a) a polynucleotide or derivative thereof and (b) a block copolymer having a polyether segment and a polyanion segment, compositions containing (a) a polynucleotide or its derivative thereof, (b) at least one polyanionic polymer, and (c) at least one amphiphilic block copolymer, and methods of using these compositions for gene therapy.
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