Method of humanizing immune system molecules
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United States of America Patent
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Issued Date -
Oct 9, 2003
app pub date -
Aug 29, 2002
filing date -
Oct 29, 2001
priority date (Note) -
Abandoned
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Abstract
Disclosed are methods for making immune system molecules, particularly humanized antibodies and fragments thereof. A typical method optimizes similarity between individual antibody framework regions to help identify human framework regions suitable for making the molecules. Comparisons between larger antibody frameworks, hypervariable domains or both is avoided. Also disclosed are antibodies that have been humanized by the method. The invention has a wide spectrum of applications including use in the production of humanized monoclonal antibodies with suitable binding affinity and minimized human immunogenicity.
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