Systems and methods for enhanced focused ultrasound ablation using microbubbles

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United States of America Patent

APP PUB NO 20030187371A1
SERIAL NO

10112252

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Abstract

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A system for performing a therapeutic procedure using focused ultrasound includes a piezoelectric transducer, drive circuitry coupled to the transducer for providing drive signals to the transducer, and a controller coupled to the drive circuitry for alternating an intensity of the drive signals between a plurality of intensities. Acoustic energy above a threshold intensity is transmitted by the transducer towards a target region to generate microbubbles in tissue within the target region. The intensity of the acoustic energy is reduced to discontinue generating microbubbles and heat the tissue, e.g., to necrose the tissue, without collapsing the generated microbubbles, the microbubbles enhancing the ability of the tissue in the target region to absorb the acoustic energy.

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Patent Owner(s)

Patent OwnerAddress
BRIGHAM AND WOMEN'S HOSPITAL INC THE75 FRANCIS STREET BOSTON MA 02115
INSIGHTEC-TXSONICS LTD39120 TIRAT-CARMEL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hynynen, Kullervo Medfield, MA 33 1279
Vitek, Shuki Haifa, IL 57 5774
Vortman, Kobi Haifa, IL 34 2006

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