Prodrugs of HIV replication inhibiting pyrimidines
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United States of America Patent
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Apr 25, 2006
Grant Date -
Oct 2, 2003
app pub date -
May 3, 2001
filing date -
May 8, 2000
priority date (Note) -
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Abstract
The present invention concerns compounds of formula (A1)(A2)N—R1 (I),the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 is substituted C1-6alkyl; —S(═O)—R8; —S(═O)2—R8; C7-12alkylcarbonyl; optionally substituted C1-6alkyloxycarbonylC1-6alkylcarbonyl; with R8 being C1-6alkyl, aryl1 or Het1; (A1)(A2)N— is the covalently bonded form of the corresponding intermediate of formula (A1)(A2)N—H, which is a HIV replication inhibiting pyrimidine of formula ##STR1##
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