Modified tetracycline repressor protein compositions and methods of use
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United States of America Patent
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Issued Date -
Oct 2, 2003
app pub date -
Dec 20, 2002
filing date -
Dec 21, 2001
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Abandoned
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Abstract
The present invention relates to a system for regulating gene expression in prokaryotes using modified tetracycline repressor proteins. In particular, the present invention relates to modified tetracycline repressor proteins that exhibit a 'reverse' phenotype in prokaryotic organisms, nucleic acids encoding these repressor proteins, methods for identifying and preparing these proteins, and methods for using these proteins for regulating gene expression in prokaryotic organisms, in drug screening assays and for identifying non-antibiotic compounds that are specific inducers of these modified repressor proteins.
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