Process for coupling amino acids to an antifolate scaffold
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United States of America Patent
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Issued Date -
Sep 25, 2003
app pub date -
Mar 22, 2002
filing date -
Mar 22, 2002
priority date (Note) -
Abandoned
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Abstract
A synthetic process is disclosed for coupling amino acids to a substrate. The process involves dissolving the amino acid and the scaffold in a non-polar aprotic solvent, and agitating the resulting mixture for a predetermined time. The process is specially suited to the synthesis of antifolate compounds having useful applications in the medical fields of oncology, inflammatory diseases and others.
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