Compositions and methods for treating cardiovascular disorders
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United States of America Patent
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Issued Date -
Sep 18, 2003
app pub date -
Feb 28, 2003
filing date -
Jul 12, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention relates compositions and methods for the prophylactic or therapeutic treatment of cardiovascular diseases, particularly restenosis and atherosclerosis. These compositions comprise an effective promotor of re-endothelialization, preferably probucol or an analogue thereof, and an inhibitor of lipoprotein oxidation, preferably a probucol-derived bisphenol. Alternatively, the said compositions may comprise a compound that possesses both re-endothelialization-promoting and lipoprotein oxidation-inhibitory effects. This invention further relates to compositions and methods for promoting re-endothelialization.
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