Enhanced mixing in microfluidic devices
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United States of America Patent
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app pub date -
Jul 19, 2002
filing date -
Nov 5, 2001
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Abstract
The present invention provides microfluidic devices and methods for enhancing mixing and hybridization kinetics in microfluidic assays. More particularly, the present invention is a device and method wherein changing the volume of a gas pocket within a microfluidic device enhances mixing and reaction kinetics therein. In an embodiment sonic frequency is applied to the gas pocket resulting in microstreaming phenomena, thereby resulting in enhanced mixing and reaction kinetics. In another embodiment, the gas pocket is fluidly connected to a microfluidic channel and the volume of the pocket is changed (e.g., by heating and cooling of the gas therein), which cause oscillating flow within the microfluidic channel, thereby resulting in enhanced mixing and reaction kinetics therein.
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